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Sunday, December 14, 2008

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Today's Top Stories

Can India and Pakistan Lower Tensions Over Kashmir?

By JYOTI THOTTAM / SRINAGAR

The terrorist strikes on Mumbai have reignited a six-decade-old dispute between India and Pakistan, with worrisome consequences for the U.S.

All Talk, Little Action, at UN Climate Change Summit

By BRYAN WALSH

Though expectations for the annual summit weren't high, thanks in part to a leadership vacuum in the U.S. and a financial meltdown around the world, neither were its accomplishments

Alternative Currencies Grow in Popularity

By JUDITH D. SCHWARTZ

Frequent Flyer miles aren't the only alternative currency. Towns around the world are inventing their own

In Olive Country, a Bitter Harvest for Migrant Workers

By LISA ABEND

Spanish olive growers rely on migrant workers every harvest season. But as recession looms, jobs are drying up

Could Blago Cause Trouble for Daley?

By ERIC FERKENHOFF / CHICAGO

John Harris, the governor's co-defendant and chief of staff, provides a link to the Chicago mayor that could come back to haunt him

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TIME Blogs

Swampland

By Joe Klein

Robin was a fine reporter and an even better person. My thoughts and prayers are with her family. She will be missed.

Special Package

1950s Sci-Fi Movies

Richard Corliss's top 10 '50s sci-fi movies

Quotes of the Day

"I don't mind losing my allowance. It goes toward other things, like groceries."

SUMIT PAL,
17, a senior at Information Technology High School in Queens, N.Y., on his parents' decision to cut his $5-per-week allowance

More Quotes

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Postcard from...

Moscow

Gloom Time for Moscow's Millionaires

By John Wendle

At the annual Millionaire Fair, there are signs that Russia's richest are feeling the pinch

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DIY Fashion Makeover in 5 Days: Day Three: Look Better in Your Clothes

DIY Fashion Makeover in 5 Days
Day Three: Look Better in Your Clothes
| Flatter your figure  | Change Your Look  | Get Fit

	from Cynthia Nellis You now know what's essential and what's hot. Now it's time to kick up your DIY makeover a notch and customize a new look that's right for you. Before you can really decide what flatters your figure, you'll need an honest assessment of your figure flaws (too busty, big hips, etc.) and a realistic sense of what you hope to accomplish (look taller, dress sexier, appear younger). The best way to get a sense of your overall shape is to stand in front of a full-length mirror and squint: you can see an outline of your body that way. What do you see? A body that is narrower through the shoulders and fuller through the hips is usually called a pear or bottom-heavy shape. A body that is wider through the shoulders, tapering down to narrower hips can either be top-heavy or athletic depending on how physically fit you are. A body that is almost equally full through the shoulders and hips with a smaller waist is called an hourglass figure. Of course there are even many variations within these general figure types: long torso, short waisted, tall, petite, etc. And you'll need to know about every problem you may face on the road to looking better in your clothes. Most of us assess our bodies only in terms of our weight (heavy, on-target or slim) and forget all of the beautiful variations that we can show off and conceal using fashion techniques. So take some time to really assess what your shape is about.
Flatter your figure
	Easy figure fixes
	Every woman has something about her body she'd like to hide, whether it's heavy thighs, a pudgy tummy or a too-round bottom. With just a few visual tricks, your problem areas will disappear and let your true beauty shine through!
Sponsored Links
	Look slimmer
	Don't cover up your figure with tent dresses! Just follow a few rules of proportion and accent your best features.
	Seem taller
	Add inches to your height visually with these 11 elongating tips.
Change Your Look
	Look Younger
	Dress younger and you'll look and feel better, too. Try our 10 easy tips for getting in touch with your inner teenager.
	Dress Sexier
	Get sexy without looking sleazy. It's easier than you think! Choose unexpected touches, glam essentials and sensuous fabrics. Perfect tips for holiday parties, romantic evenings or any time you want to get in touch with your inner goddess.
Get Fit
	Measure Up
	Find out how to measure to get your true size.
Cynthia Nellis
Learn Something New Every Day
Enroll at About U for More Online Learning About U is our collection of free online courses on About.com. Each online course is sent to you via email on a daily or weekly basis and will help you learn new skills, solve common problems, find shortcuts and quick tricks to simplify your busy life, or just learn more about your world.

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Party Perfect in 5 Days: Day Three: Start Shopping

Party Perfect in 5 Days
Day Three: Start Shopping
| How to Shop

	from Cynthia Nellis Looking for the perfect dress is half the fun of going to a special event. Just remember to save enough time to do it right. The most efficient way is to shop by yourself; the most fun way is to shop with a friend. Your choice!
How to Shop
	Step-By-Step Instructions on How to Shop
	These tips for smarter shopping will help you buy a better wardrobe by spending less time and money.
Sponsored Links
	Shop in a Ritzy Store
	Dress shopping may take you into chi chi stores you don't feel comfortable in. Follow our tips and shop like a pro.
	How to Shop in a Hurry
	Are you out of time for the big event? Then use some quick tips to get you ready to shop the mall in a flash.
	7 Secrets of Highly Successful Sale Shoppers
	Successful sale shopping for a formal dress isn't like a trip to the grocery store: coupon clipping won't likely score you any big discounts off of the dress you really want. Find the secret to getting great stuff for a steal.
Cynthia Nellis
Learn Something New Every Day
Enroll at About U for More Online Learning About U is our collection of free online courses on About.com. Each online course is sent to you via email on a daily or weekly basis and will help you learn new skills, solve common problems, find shortcuts and quick tricks to simplify your busy life, or just learn more about your world.

Search About

Missing Lesson: http://fashion.about.com/c/ec/1lost.htm

Cancel Subscription: You are receiving this email because you subscribed to the About Day Three: Start Shopping as fpac.rangola@blogger.com. If you no longer wish to receive emails from us, please click here: http://about.com/nl/usec.htm?nl=fashion_1&e=fpac.rangola@blogger.com About respects your privacy. Our Privacy Policy. Our Contact Information. 249 West 17th Street New York, NY, 10011 © 2008 About, Inc.

Presspass - News Edition

	Charleston.net News Commercial Real Estate Residential Real Estate Subscribe to the Post & Courier Place a Classified Ad	A patriot's return
			John Almeida grew up idolizing an uncle he never met. Marion Ryan McCown was a pilot, a Golden Gloves boxer and a sailor â€" a true Lowcountry prince of tides. All his life, Almeida was inspired by the family stories of his mother's brother, including the one that had no ending. There were the tales of young adventure when McCown was a Boy Scout exploring the South Carolina salt marshes; his time as a student as Georgia Tech in Atlanta; the time he got his pilot's license.
Enjoy a every Sunday Only In The Post & Courier find locations		When season ends, the questions begin He has stood on the Summerville sideline for what seems forever. He has won more games than anyone else. He's old, 82. Every year could be his last. But John McKissick knows â€" there's no place he'd rather be. This is the last of an eight-part series. Previously: Times change, and so do the players. Summerville wrapped up its regular season. Program collects 242 guns Bob Rousseau loaded six old guns into his car Saturday morning and dropped them off at North Charleston's first gun "buyback" at Mount Moriah Missionary Baptist Church. He had been storing his father's old guns in a locked closet for a long time. But, he said, "I've been feeling unsafe with them around the house." He had thought about taking them to a pawn shop but suspected the guns might end up in the hands of a criminal. He was relieved to finally have a safe place to get rid of them. Owner moving ahead on landfill proposal ADAMS RUN â€" Wilbur Jones spent much of his childhood hunting in the woods in southwestern Charleston County. Jones, now in his 60s, is one of many residents and landowners in the rural community off U.S. Highway 17 near Parkers Ferry Road fighting to stop a private company from building a landfill for construction waste in the area. He wants to protect the fragile, low-lying environment for future generations. Enforcement blitz begins for holidays Police kicked off their traffic-enforcement blitz for the holiday season with a grim comparison: murders and drunken driving fatalities. An average of 315 people are slain in South Carolina every year. But an average of 422 will die annually in alcohol-related crashes.
Today | News | Sports | Entertainment | Features | Web Extras | Editorial | Obituaries | Blogs | Archives The Post and Courier | Charleston.net | 134 Columbus St. | Charleston | SC | 29403

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Presspass - Sports Edition

	Charleston.net News Commercial Real Estate Residential Real Estate Subscribe to the Post & Courier Place a Classified Ad	Oklahoma QB Bradford edges McCoy, Tebow for Heisman
			NEW YORK â€" Sam Bradford's biggest score: the Heisman Trophy. Oklahoma's amazingly accurate and quick-thinking quarterback won the Heisman on Saturday night after guiding the highest-scoring team in major college football history to the national championship game. A year after Tim Tebow became the first sophomore to win the Heisman, Bradford became the second and kept the Florida QB from joining Archie Griffin as the only two-time winners.
		S.C. State no problem for Tigers CLEMSON â€" Oliver Purnell's continually ascending Clemson basketball program is doing the things necessary to appear in the NCAA Tournament for the second straight March. Tim Carter's upstart South Carolina State Bulldogs might get there, too. But their path is longer and requires heavier coats. Clemson improved to 10-0 Saturday with a 90-63 victory before a crowd of 5,927 at Littlejohn Coliseum. Seeking perfect home mark, hot Panthers battle Broncos CHARLOTTE â€" The game was moved to the coveted Sunday night spot. It could determine the No. 1 seed, home-field advantage throughout the NFC playoffs, and if the Carolina Panthers really deserve to be considered one of NFL's elite teams. Trouble is, that game isn't until next weekend. Before the Panthers (10-3) visit the Super Bowl champion New York Giants, they must first face the Denver Broncos (8-5) today (4:15 p.m., WCSC-TV), a tricky game six days after Monday's emotional win over top rival Tampa Bay. DNR increases fees for boating services New watercraft service fee increases went into effect Dec. 11. The fee increases were incorporated into the boating bill recently passed by the S.C. General Assembly. The revenue generated from the fee increase will help cover S.C. Department of Natural Resources (DNR) administrative costs of forms, decals and other operation expenses. Bulletin Board
Today | News | Sports | Entertainment | Features | Web Extras | Editorial | Obituaries | Blogs | Archives The Post and Courier | Charleston.net | 134 Columbus St. | Charleston | SC | 29403

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Presspass - Business Edition

	Charleston.net News Commercial Real Estate Residential Real Estate Subscribe to the Post & Courier Place a Classified Ad	Preparing for 'hire' education
			South Carolina's new immigration law could make businesses such as Pleasant Places landscaping not so pleasant for workers in the country illegally or for the company itself. About 90 percent of the Mount Pleasant-based landscaper's labor force is Hispanic, said Jason James, general manage...
		Former Nasdaq chairman may have swindled investors out of billions Investors were scrambling Friday to learn whether they had been wiped out by what prosecutors described as a massive Ponzi scheme allegedly perpetrated by 70-year-old Bernard L. Madoff. The scam is shaping up to be one of the largest frauds in Wall Street history. How the world's best mutual-fund manager self-destructed Bill Miller’s Legg Mason Value Trust outperformed the broad market every year from 1991 to 2005. a a streak no other fund manager has come close to matching. But after 15 years of placing savvy bets against the herd, Miller ended up getting trampled by it. Cuban tourism surges as rest of Caribbean stalls While the communist-controlled island suffered three devastating hurricanes, key tourist sites were largely spared. And where beachfront resorts did get hit, the tourist-hungry government has made sure to repair hotels â€" in some cases even before damaged homes and infrastructure. The hospitality industry is Cuba’s second-largest source of foreign income. Hendrick employee returns Bob Hamlin, a veteran of the car business, has rejoined the sales department at Hendrick Honda in Charleston as a senior sales consultant.
Today | News | Sports | Entertainment | Features | Web Extras | Editorial | Obituaries | Blogs | Archives The Post and Courier | Charleston.net | 134 Columbus St. | Charleston | SC | 29403

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HIV/AIDS Update - PEPFAR-related tentative approval of generic efavirenz

You are receiving this message as a subscriber to the FDA HIV/AIDS electronic list serve. The purpose of the list serve is to relay important information about HIV/AIDS-related products and issues, including product approvals, significant labeling changes, safety warnings, notices of upcoming public meetings and alerts to proposed regulatory guidances for comment.

Please do not reply to this message.

On December 12, 2008, FDA granted tentative approval for efavirenz 100 mg scored tablets, indicated in combination with other antiretrovirals for the treatment of HIV-1 infection, facilitating pediatric treatment.  The product is manufactured by Aurobindo Pharma Limited, Hyberdad, India.

Efavirenz is an antivral agent in the Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) class.

"Tentative approval" means that FDA has concluded that a drug product meets all required quality, safety and efficacy standards, but is not eligible for marketing in the U.S. because of existing patents and/or exclusivity rights. However, tentative approval does make the product eligible for purchase outside the United States under the President’s Emergency Plan for AIDS Relief (PEPFAR) .

The application was reviewed under expedited review provisions developed by FDA for the PEPFAR program

This tentative approval is a generic version of Sustiva, which is a product of Bristol Myers-Squibb, and is subject to existing patent protection. Effective patent dates can be found in the agency's publication titled Approved Drug Products with Therapeutic Equivalence Evaluations, also known as the "Orange Book"

As with all generic applications, FDA conducts an on-site inspection of each manufacturing facility, and of the facilities performing the bioequivalence studies, to evaluate the ability of the manufacturer to produce a quality product and to assess the quality of the bioequivalence data supporting the application prior to granting approval or tentative approval to these applications.

A list of all Approved and Tentatively Approved Antiretrovirals in Association with the President's Emergency Plan is available on the FDA website.

Richard Klein
Office of Special Health Issues
Food and Drug Administration

Kimberly Struble
Division of Antiviral Drug Products
Food and Drug Administration 

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